Title : Insulin-like growth factor-I inhibits endogenous acetylcholine release from the rat hippocampal formation: possible involvement of GABA in mediating the effects.

Pub. Date : 2002

PMID : 12421625






6 Functional Relationships(s)
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1 Insulin-like growth factor-I inhibits endogenous acetylcholine release from the rat hippocampal formation: possible involvement of GABA in mediating the effects. gamma-Aminobutyric Acid insulin-like growth factor 1 Rattus norvegicus
2 The inhibitory effects of IGF-I on hippocampal ACh release were not additive to those of either muscimol or baclofen, but were attenuated by GABA antagonists, bicuculline and phaclofen. gamma-Aminobutyric Acid insulin-like growth factor 1 Rattus norvegicus
3 Furthermore, the evidence that effects of IGF-I could be modulated, at least in part, by GABA antagonists suggest that the release of GABA and the activation of its receptors may possibly be involved in mediating the inhibitory effects of IGF-I on hippocampal ACh release. gamma-Aminobutyric Acid insulin-like growth factor 1 Rattus norvegicus
4 Furthermore, the evidence that effects of IGF-I could be modulated, at least in part, by GABA antagonists suggest that the release of GABA and the activation of its receptors may possibly be involved in mediating the inhibitory effects of IGF-I on hippocampal ACh release. gamma-Aminobutyric Acid insulin-like growth factor 1 Rattus norvegicus
5 Furthermore, the evidence that effects of IGF-I could be modulated, at least in part, by GABA antagonists suggest that the release of GABA and the activation of its receptors may possibly be involved in mediating the inhibitory effects of IGF-I on hippocampal ACh release. gamma-Aminobutyric Acid insulin-like growth factor 1 Rattus norvegicus
6 Furthermore, the evidence that effects of IGF-I could be modulated, at least in part, by GABA antagonists suggest that the release of GABA and the activation of its receptors may possibly be involved in mediating the inhibitory effects of IGF-I on hippocampal ACh release. gamma-Aminobutyric Acid insulin-like growth factor 1 Rattus norvegicus