Title : Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.

Pub. Date : 2002 Nov 1

PMID : 12414639






1 Functional Relationships(s)
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1 Treatment of PC-3 PTEN-negative cells with rapamycin inhibited 70-kDa S6 kinase and increased the proliferative response of these cells to doxorubicin, so that it was comparable with the responses of PTEN-positive DU-145 cells and the PC-3-transfected cells. Sirolimus phosphatase and tensin homolog Homo sapiens