Pub. Date : 2002 Oct
PMID : 12406022
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6. | Histamine | interleukin 6 | Homo sapiens |
| 2 | RESULTS: IL-6 inhibited the proliferation of WM35 melanoma cells and increased significantly the expression of histidine decarboxylase as well as histamine production. | Histamine | interleukin 6 | Homo sapiens |
| 3 | CONCLUSION: We suggest that the growth arrest induced by IL-6 is in part mediated by its dual action on histamine: a shift toward H1 receptor predominance and an elevation of locally produced histamine with prevalent action on the inhibitory response triggered through the H1 receptor. | Histamine | interleukin 6 | Homo sapiens |
| 4 | CONCLUSION: We suggest that the growth arrest induced by IL-6 is in part mediated by its dual action on histamine: a shift toward H1 receptor predominance and an elevation of locally produced histamine with prevalent action on the inhibitory response triggered through the H1 receptor. | Histamine | interleukin 6 | Homo sapiens |