Title : Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.

Pub. Date : 2002

PMID : 12405865






1 Functional Relationships(s)
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1 Rifampicin (rifampin), phenobarbital, phenytoin, carbamazepine, nevirapine, and efavirenz decrease methadone blood concentrations, probably by induction of CYP3A4 activity, which can result in severe withdrawal symptoms. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens