Title : [Anti-inflammatory non-steroidal selective cyclooxygenase 2 inhibitors and gastroduodenal lesions].

Pub. Date : 2002 Sep 28

PMID : 12395741






1 Functional Relationships(s)
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1 ULCER COMPLICATIONS: The probability of developing a symptomatic, uncomplicated or complicated (perforation, gastric outlet obstruction, bleeding) gastroduodenal ulcer is significantly lower with a COX-2 selective inhibitor (Celecoxib, rofecoxib) than with a traditional NSAIDs, with a reduction in absolute risk of around 1-1.5 for 100 patient-years in clinical trials. rofecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens