Title : A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding.

Pub. Date : 2002 Oct 30

PMID : 12392404






2 Functional Relationships(s)
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1 A series of tethered quaternary ammonium derivatives of Tyr have been incorporated into the binding site of the nicotinic acetylcholine receptor (nAChR) using the in vivo nonsense suppression method, producing constitutively active (self-gating) receptors. quaternary ammonium cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 A series of tethered quaternary ammonium derivatives of Tyr have been incorporated into the binding site of the nicotinic acetylcholine receptor (nAChR) using the in vivo nonsense suppression method, producing constitutively active (self-gating) receptors. quaternary ammonium cholinergic receptor nicotinic alpha 4 subunit Homo sapiens