Pub. Date : 2002 Nov
PMID : 12391142
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Mus musculus |
| 2 | Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Mus musculus |
| 3 | Overexpression of Hsp72 also inhibited H(2)O(2)-induced activation of ASK1 as well as that of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Mus musculus |
| 4 | Hsp72 antisense oligonucleotides prevented the inhibitory effects of mild heat shock on H(2)O(2)-induced ASK1 activation and apoptosis. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Mus musculus |