Pub. Date : 2002 Nov
PMID : 12388652
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results show that LAAM, methadone, fentanyl, and buprenorphine were effective inhibitors of I(HERG), with IC(50) values in the 1 to 10 microM range. | Methadone | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |
| 2 | Further investigation showed that methadone block of I(HERG) was rapid, with steady-state inhibition achieved within 1 s when applied at its IC(50) concentration (10 microM) for I(HERG) block. | Methadone | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |
| 3 | Further investigation showed that methadone block of I(HERG) was rapid, with steady-state inhibition achieved within 1 s when applied at its IC(50) concentration (10 microM) for I(HERG) block. | Methadone | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |
| 4 | These results demonstrate that LAAM and methadone can block I(HERG) in transfected cells at clinically relevant concentrations, thereby providing a plausible mechanism for the adverse cardiac effects observed in some patients receiving LAAM or methadone. | Methadone | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |
| 5 | These results demonstrate that LAAM and methadone can block I(HERG) in transfected cells at clinically relevant concentrations, thereby providing a plausible mechanism for the adverse cardiac effects observed in some patients receiving LAAM or methadone. | Methadone | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |