Title : Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.

Pub. Date : 2002 Oct 15

PMID : 12384525






3 Functional Relationships(s)
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1 In the mouse, the promotional effect of PB on liver tumor development results from a selective stimulation of clonal outgrowth of hepatocytes harboring activating mutations in the beta-catenin gene. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
2 We have previously shown that beta-catenin mutations are present in approximately 80% of liver tumors from PB-treated mice but are absent in liver tumors from mice treated with DEN only. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
3 These data suggest that promotion of hepatocarcinogenesis by PB confers beta-catenin-mutated tumor cells with a selective advantage by up-regulation of GS expression. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus