Title : Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.

Pub. Date : 2002 Sep 15

PMID : 12383707






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibition of ERK eliminated BP-induced QR activity, whereas inhibition of p38 had no effect on QR activity. Benzo(a)pyrene mitogen-activated protein kinase 1 Homo sapiens
2 Treatment of cells with 10 nM BP increased [(3)H]thyd incorporation by 50% after 48 h. This increase was eliminated by ERK but not p38 inhibition. Benzo(a)pyrene mitogen-activated protein kinase 1 Homo sapiens
3 In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity. Benzo(a)pyrene mitogen-activated protein kinase 1 Homo sapiens
4 In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity. Benzo(a)pyrene mitogen-activated protein kinase 1 Homo sapiens