Title : Internal dynamics and ionization states of the macrophage migration inhibitory factor: comparison between wild-type and mutant forms.

Pub. Date : 2002 Nov 15

PMID : 12382291






1 Functional Relationships(s)
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1 Two hypotheses have been proposed to explain the catalytic inefficiency of MIF: the lower basicity of primary amines with regard to secondary ones and the increased flexibility resulting from the replacement of a proline by residues like glycine. Proline macrophage migration inhibitory factor Homo sapiens