Title : The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone.

Pub. Date : 2002 Oct

PMID : 12379510






6 Functional Relationships(s)
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1 The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone. Prednisolone ATP binding cassette subfamily B member 1 Homo sapiens
2 In the present study, we have investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in hampering the access of the synthetic glucocorticoid, prednisolone. Prednisolone ATP binding cassette subfamily B member 1 Homo sapiens
3 In the present study, we have investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in hampering the access of the synthetic glucocorticoid, prednisolone. Prednisolone ATP binding cassette subfamily B member 1 Homo sapiens
4 In vitro, in stably transfected LLC-PK1 monolayers the human MDR1 P-glycoprotein was able to transport prednisolone present at a micromolar concentration. Prednisolone ATP binding cassette subfamily B member 1 Homo sapiens
5 The ability of Pgp to export the synthetic glucocorticoid, prednisolone, suggests that uptake of prednisolone in the human brain is impaired, leading to a discrepancy between central and peripheral actions. Prednisolone ATP binding cassette subfamily B member 1 Homo sapiens
6 The ability of Pgp to export the synthetic glucocorticoid, prednisolone, suggests that uptake of prednisolone in the human brain is impaired, leading to a discrepancy between central and peripheral actions. Prednisolone ATP binding cassette subfamily B member 1 Homo sapiens