Title : The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor.

Pub. Date : 2002 Oct 14

PMID : 12379151






1 Functional Relationships(s)
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1 BACKGROUND: Huntington"s disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein"s unknown inherent function. polyglutamine huntingtin Drosophila melanogaster