Title : Molecular determinants of sugar transport regulation by ATP.

Pub. Date : 2002 Oct 22

PMID : 12379105






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Intracellular ATP inhibits human erythrocyte net sugar transport by binding cooperatively to the glucose transport protein (GluT1). Sugars solute carrier family 2 member 1 Homo sapiens
2 (2002) Biochemistry 41, 12639-12651) demonstrates that reduced intracellular pH promotes high-affinity ATP binding to GluT1 but inhibits ATP-modulation of GluT1-mediated sugar transport. Sugars solute carrier family 2 member 1 Homo sapiens
3 In HEK cells, both parental GluT1- and GluT1.HA.H6-mediated sugar transport are acutely sensitive to cellular metabolic inhibition. Sugars solute carrier family 2 member 1 Homo sapiens
4 In HEK cells, both parental GluT1- and GluT1.HA.H6-mediated sugar transport are acutely sensitive to cellular metabolic inhibition. Sugars solute carrier family 2 member 1 Homo sapiens
5 It is proposed that cooperative nucleotide binding to GluT1 and nucleotide modulation of GluT1-mediated sugar transport are regulated by a proton-sensitive saltbridge (Glu329-Arg333/334). Sugars solute carrier family 2 member 1 Homo sapiens