Title : TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells.

Pub. Date : 2002 Nov

PMID : 12376363






2 Functional Relationships(s)
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1 A chemical inhibitor of p38 MAPK (SB-203580) abolished TGF-beta1-inducible HO-1 mRNA expression. SB 203580 heme oxygenase 1 Homo sapiens
2 Both SB-203580 and expression of a dominant-negative mutant of p38 MAPK inhibited TGF-beta1-induced ho-1 gene activation, as assayed by luciferase activity of an ho-1 enhancer/luciferase fusion construct (pMHO1luc-33+SX2). SB 203580 heme oxygenase 1 Homo sapiens