Pub. Date : 2002 Oct 15
PMID : 12370413
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 5 | We found that activation of PXR also increases the activity and gene expression of the phase II conjugating enzyme dehydroepiandrosterone sulfotransferase (STD) known to sulfate LCA to facilitate its elimination. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |