Title : Glycine rich P-loop motif in deoxyuridine pyrophosphatase.

Pub. Date : 2001 Dec

PMID : 12369927






4 Functional Relationships(s)
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1 Similar to other nucleotide binding proteins, dUTPase also consists of a sequence motif rich in glycine residues known as P-loop motif. Glycine Deoxyuridine triphosphatase Drosophila melanogaster
2 One of the main reasons for this limited information is the lack of the three-dimensional structure of a dUTPase enzyme with an ordered Gly-rich P-loop motif with a bound substrate and Mg(2+) ion. Glycine Deoxyuridine triphosphatase Drosophila melanogaster
3 This review presents an insight into the role of Gly-rich P-loop motif in the function of dUTPase as revealed from the crystal structure. Glycine Deoxyuridine triphosphatase Drosophila melanogaster
4 The analysis reveals the Gly-rich P-loop motif of dUTPase to be the longest in terms of its amino-acid composition as compared to other nucleotide binding proteins and exhibit a high-degree of sequence conservation among spectrum of species. Glycine Deoxyuridine triphosphatase Drosophila melanogaster