Pub. Date : 2002 Aug
PMID : 12363040
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 2 | Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 3 | We characterized the jasplakinolide-induced loss of viability by programmed cell death in the HL-60 human promyelocytic leukemia cell line and found that this process was accompanied by neutral endopeptidase (NEP)/CD10 expression on the surface of the apoptotic cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 4 | We characterized the jasplakinolide-induced loss of viability by programmed cell death in the HL-60 human promyelocytic leukemia cell line and found that this process was accompanied by neutral endopeptidase (NEP)/CD10 expression on the surface of the apoptotic cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 5 | We characterized the jasplakinolide-induced loss of viability by programmed cell death in the HL-60 human promyelocytic leukemia cell line and found that this process was accompanied by neutral endopeptidase (NEP)/CD10 expression on the surface of the apoptotic cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 6 | HL-60 cells do not normally express detectable amounts of NEP/CD10 on their surface or intracytoplasmically, but upon jaspamide treatment, CD10 was synthesized de novo, its expression being inhibited by cycloheximide pretreatment. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 7 | Once synthesized, NEP/CD10 interfered with the jasplakinolide signal delivered to HL-60 cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 8 | Once synthesized, NEP/CD10 interfered with the jasplakinolide signal delivered to HL-60 cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |
| 9 | Our findings suggest that the CD10 expression is related to the programmed cell death induction by jaspamide, and also with the process of granulocytic differentiation in HL-60 cells. | jasplakinolide | membrane metalloendopeptidase | Homo sapiens |