Title : A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism.

Pub. Date : 2002 Oct

PMID : 12358742






5 Functional Relationships(s)
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1 A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tumor protein p53 Homo sapiens
2 p53 is a target of the nuclear enzyme Poly(ADP-ribose)polymerase (PARP), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tumor protein p53 Homo sapiens
3 p53 is a target of the nuclear enzyme Poly(ADP-ribose)polymerase (PARP), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tumor protein p53 Homo sapiens
4 We find that p53 is heavily poly(ADP-ribosyl)ated by PARP-1 following MPTP intoxication. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tumor protein p53 Homo sapiens
5 These influences of PARP-1 on p53 may underlie the mechanisms of MPTP-induced parkinsonism and other models of neuronal death. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tumor protein p53 Homo sapiens