Pub. Date : 2002 Oct
PMID : 12358742
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | tumor protein p53 | Homo sapiens |
| 2 | p53 is a target of the nuclear enzyme Poly(ADP-ribose)polymerase (PARP), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | tumor protein p53 | Homo sapiens |
| 3 | p53 is a target of the nuclear enzyme Poly(ADP-ribose)polymerase (PARP), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | tumor protein p53 | Homo sapiens |
| 4 | We find that p53 is heavily poly(ADP-ribosyl)ated by PARP-1 following MPTP intoxication. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | tumor protein p53 | Homo sapiens |
| 5 | These influences of PARP-1 on p53 may underlie the mechanisms of MPTP-induced parkinsonism and other models of neuronal death. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | tumor protein p53 | Homo sapiens |