Title : Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.

Pub. Date : 2002 Sep 30

PMID : 12351158






1 Functional Relationships(s)
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1 A novel CYP1A2-derived metabolite was characterized as 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid (IQx-8-COOH) and was the predominant metabolite formed in human hepatocytes exposed to MeIQx at levels approaching human exposure. 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline cytochrome P450 family 1 subfamily A member 2 Homo sapiens