Title : The connexin43 gap junction protein is phosphorylated by protein kinase A and protein kinase C: in vivo and in vitro studies.

Pub. Date : 2002 Sep

PMID : 12349910






1 Functional Relationships(s)
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1 Using a combination of in vivo metabolic labeling and in vitro phosphorylation of recombinant protein and synthetic peptides, we now find that connexin43 is a relatively poor substrate for purified protein kinase A compared to protein kinase C, but that phosphorylation can be accelerated by 8-Br-cAMP (8-bromoadenosine 3",5"-cyclic monophosphate) which also enhances connexin43 synthesis but at a much slower rate than phosphorylation. 8-Bromo Cyclic Adenosine Monophosphate gap junction protein alpha 1 Homo sapiens