Title : Dramatic rate enhancement with preservation of stereospecificity in the first metal-catalyzed additions of allylboronates.

Pub. Date : 2002 Oct 2

PMID : 12296710






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1 Using a novel class of isomerically pure, tetrasubstituted 2-alkoxycarbonyl allylboronates (1), we describe that some metals (for example, Sc(OTf)(3) and Cu(OTf)(2)) allow these reagents to add onto aldehydes to yield gamma-lactone products 2 in good yields at temperatures almost 100 degrees C lower than the corresponding uncatalyzed reactions. 4-hexanolide POU class 5 homeobox 1 Homo sapiens