Title : Cloning and functional characterization of the guinea pig vanilloid receptor 1.

Pub. Date : 2002 Sep

PMID : 12243775






2 Functional Relationships(s)
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1 Capsaicin produced a concentration-dependent increase in intracellular calcium in guinea pig VR1-CHO cells with an estimated EC(50) of 0.17 +/- 0.0065 micro M, similar to that previously reported for rat and human VR1. Capsaicin transient receptor potential cation channel subfamily V member 1 Cavia porcellus
2 Capsazepine acted as an antagonist of capsaicin responses in guinea pig VR1-CHO cells (IC(50) of 0.324 +/- 0.041 micro M ), as seen at rat VR1. Capsaicin transient receptor potential cation channel subfamily V member 1 Cavia porcellus