Title : High affinity antagonists of the vanilloid receptor.

Pub. Date : 2002 Oct

PMID : 12237342






2 Functional Relationships(s)
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1 The vanilloid receptor VR1 has attracted great interest as a sensory transducer for capsaicin, protons, and heat, and as a therapeutic target. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 We conclude that JYL1421 is a competitive antagonist of rVR1, blocking response to all three of the agonists (capsaicin, heat, and protons) with enhanced potency relative to capsazepine. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus