Title : Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.

Pub. Date : 2002 Nov 29

PMID : 12237321






1 Functional Relationships(s)
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1 alpha(V)beta(3)-mediated adhesion induced a transient COX-2-dependent rise in cAMP levels, whereas the cell-permeable cAMP analogue 8-brcAMP accelerated adhesion, promoted Rac activation, and cell spreading in the presence of the COX-2 inhibitor NS-398. 8-Bromo Cyclic Adenosine Monophosphate AKT serine/threonine kinase 1 Homo sapiens