Pub. Date : 2002 Nov 29
PMID : 12237321
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here we investigated the role of the COX-2 metabolites PGE(2) and TXA2 in regulating human umbilical vein endothelial cell (HUVEC) adhesion and spreading. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
2 | In conclusion, these results demonstrate that PGE(2) accelerates alpha(V)beta(3)-mediated endothelial cell adhesion through cAMP-dependent PKA activation and induces alpha(V)beta(3)-dependent spreading via cAMP- and PKA-dependent Rac activation and may contribute to the further understanding of the regulation of vascular integrins alpha(V)beta(3) by COX-2/PGE(2) during tumor angiogenesis and inflammation. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |