Title : Modulation of polyglutamine-induced cell death by genes identified by expression profiling.

Pub. Date : 2002 Sep 15

PMID : 12217956






1 Functional Relationships(s)
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1 In order to model HD pathogenesis in a controlled system, we developed stable PC12 cell lines that express exon 1 fragments of the huntingtin gene with 23 or 74 polyglutamines driven by an inducible doxycycline (dox)-sensitive promoter (HD-23Q or HD-74Q). polyglutamine huntingtin Rattus norvegicus