Title : Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

Pub. Date : 2002 Nov 22

PMID : 12215434






1 Functional Relationships(s)
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Protein Name
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1 Copper and iron levels both show marked increases with age and may adversely interact with the amyloid-beta (Abeta) peptide causing its aggregation and the production of neurotoxic hydrogen peroxide (H(2)O(2)), contributing to the pathogenesis of AD. Hydrogen Peroxide amyloid beta (A4) precursor protein Mus musculus