Title : Oxidant-induced inhibition of myocardial calcium-independent phospholipase A2.

Pub. Date : 2001

PMID : 12213969






2 Functional Relationships(s)
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1 We discovered the acute inhibition of myocardial phospholipase A2 activity by micromolar concentrations of tert-butyl hydroperoxide and hydrogen peroxide. tert-Butylhydroperoxide phospholipase A2 group IB Rattus norvegicus
2 This conclusion was further validated by the experiments in which pretreatment with the calcium-independent phospholipase A2 inhibitor bromoenol lactone exacerbated cardiotoxicity of tert-butyl hydroperoxide in myocyte cultures. tert-Butylhydroperoxide phospholipase A2 group IB Rattus norvegicus