Title : Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

Pub. Date : 2002 Nov 8

PMID : 12213802






1 Functional Relationships(s)
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1 H2O2 produced early activation of Akt/PKB and also DNA damage that was followed by stabilization of p53 levels, formation of reactive oxygen species (ROS), and generation of ceramide through activation of a glutathione-sensitive neutral sphingomyelinase. Hydrogen Peroxide tumor protein p53 Homo sapiens