Title : Androgens block interleukin-1 beta-induced promatrilysin expression in prostate carcinoma cells.

Pub. Date : 2002 Sep 15

PMID : 12210475






2 Functional Relationships(s)
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1 Furthermore, testosterone completely abrogated NF kappa B transactivation activity and induction of IL-6 protein expression and mRNA. Testosterone nuclear factor kappa B subunit 1 Homo sapiens
2 CONCLUSION: From these data, we conclude that testosterone blocks IL-1 beta-induced promatrilysin expression by inhibition of NF kappa B transactivation activity, which in turn, blocks IL-6 expression. Testosterone nuclear factor kappa B subunit 1 Homo sapiens