Title : A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro.

Pub. Date : 2002 Sep

PMID : 12210046






2 Functional Relationships(s)
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1 Previous studies in our laboratory have shown that excipients such as poly(ethylene)glycol (PEG)-300, Cremophor EL, and Tween 80 inhibit P-gp activity in Caco-2 cell monolayers. Polyethylene Glycols ATP binding cassette subfamily B member 1 Homo sapiens
2 PEG-induced changes in P-gp activity are probably related to changes in the fluidity of the polar head group regions of cell membranes. Polyethylene Glycols ATP binding cassette subfamily B member 1 Homo sapiens