Pub. Date : 2002 Oct
PMID : 12209884
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 2 | Flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone showed the dose-dependent inhibition on TPA-stimulated MAPK phosphorylation, COX-2, ODC, c-Jun protein expressions. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 3 | And, PD98059, a specific inhibitor of ERKs, inhibited TPA-induced MAPK phosphorylation, accompanied by decreasing COX-2, c-Jun, and ODC protein expression, and showed dose-dependent inhibition on TPA-induced proliferation in cells. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 4 | These results demonstrated that PGE(2) is an important mediator in TPA-induced proliferation, and MAPK phosphorylation was located at the upstream of COX-2, c-Jun, and ODC gene expressions in TPA-induced responses. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 5 | Furthermore, flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone (100 microM) suppressed TPA-induced colony formation associated with blocking MAPK phosphorylation, ODC, c-Jun, and COX-2 proteins expression. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |