Title : Extracellular adenine nucleotides modulate cytokine production by human monocyte-derived dendritic cells: dual effect on IL-12 and stimulation of IL-10.

Pub. Date : 2002 Sep

PMID : 12207325






2 Functional Relationships(s)
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Protein Name
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1 We observed that ATPgammaS potentiated the IL-12p40 release induced by TNF-alpha, but also by lipopolysaccharides (LPS) and soluble CD40 ligand (sCD40L). adenosine 5'-O-(3-thiotriphosphate) tumor necrosis factor Homo sapiens
2 The combinations ATPgammaS-TNF-alpha and ATPgammaS-sCD40L were unable to induce detectable bioactive IL-12p70 production and at concentrations of LPS that induced a significant stimulation of IL-12p70, the effect of ATPgammaS was purely inhibitory. adenosine 5'-O-(3-thiotriphosphate) tumor necrosis factor Homo sapiens