Title : Signal pathways involved in the production of MMP-1 and MMP-3 in human gingival fibroblasts.

Pub. Date : 2002 Aug

PMID : 12206592






1 Functional Relationships(s)
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1 The upregulation of MMPs, induced by IL-1beta or TNFalpha, was reduced by the cyxlooxygenase-2 (COX-2) inhibitor NS-398, the p38 MAP-kinase inhibitor SB 203580, and the tyrosine kinase inhibitor herbimycin A. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide tumor necrosis factor Homo sapiens