Pub. Date : 2002 Nov 8
PMID : 12202486
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 2 | We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 3 | We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 4 | We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 5 | We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 6 | EGFr phosphorylation causes extracellular signal-regulated kinase (ERK) activation and inhibits CCh-stimulated chloride secretion across intestinal epithelial cells. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 7 | Here we investigated whether CCh-stimulated EGFr transactivation involves EGFr ligand release. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 8 | Here we investigated whether CCh-stimulated EGFr transactivation involves EGFr ligand release. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 9 | Pre-incubation of T(84) cell monolayers with a neutralizing antibody to the EGFr ligand binding domain decreased CCh-induced phosphorylation of EGFr and ERK. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 10 | Pre-incubation of T(84) cell monolayers with a neutralizing antibody to the EGFr ligand binding domain decreased CCh-induced phosphorylation of EGFr and ERK. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 11 | CCh-stimulated efflux of (86)Rb+ from T(84) cell monolayers, which parallels changes in chloride secretion, was potentiated by anti-EGFr pre-incubation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 12 | Co-incubation with the Src kinase inhibitor PP2 and anti-EGFr had an additive inhibitory effect on CCh-induced ERK phosphorylation greater than either inhibitor alone. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 13 | We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 14 | We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation. | Carbachol | epidermal growth factor receptor | Homo sapiens |