Pub. Date : 2002 Oct 18
PMID : 12200414
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons. | Calcium | huntingtin | Homo sapiens |
| 2 | Exposure of primary neurons to glutamate or 3-nitropropionic acid increases intracellular calcium concentration, leading to loss of intact full-length wild-type huntingtin. | Calcium | huntingtin | Homo sapiens |
| 3 | Degradation of wild-type huntingtin by calcium-dependent proteases thus occurs in HD neurons, leading to loss of wild-type huntingtin neuroprotective activity. | Calcium | huntingtin | Homo sapiens |
| 4 | Degradation of wild-type huntingtin by calcium-dependent proteases thus occurs in HD neurons, leading to loss of wild-type huntingtin neuroprotective activity. | Calcium | huntingtin | Homo sapiens |