Title : Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing.

Pub. Date : 2002 Nov 8

PMID : 12196530






1 Functional Relationships(s)
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1 Introduction of multiple glycine substitutions into the N-terminal segment of the A chain (residues A1-A5) yields analogs that are less stable than native insulin and essentially without biological activity. Glycine insulin Homo sapiens