Title : COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells.

Pub. Date : 2002 Sep

PMID : 12193665






1 Functional Relationships(s)
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1 Acute treatment with the protein tyrosine kinase inhibitor, tyrphostin 25, inhibited basal and IL-1 beta-induced COX activities, suggesting the importance of posttranslational modifications in endothelial COX-2 activation in human brain. Tyrphostins mitochondrially encoded cytochrome c oxidase II Homo sapiens