Title : 5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2.

Pub. Date : 2002 Oct 25

PMID : 12193593






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tyrphostin AG490, a specific inhibitor of Jak-2, significantly reduced tyrosine phosphorylation and DNA binding activity of STAT-3 and DNA synthesis induced by 5(S)-HETE. Tyrphostins signal transducer and activator of transcription 3 Homo sapiens