Title : Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine.

Pub. Date : 2002 Sep

PMID : 12183670






2 Functional Relationships(s)
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1 Bupropion, an efficacious antidepressant and smoking cessation agent, inhibits dopamine and norepinephrine transporters (DAT and NET, respectively). Bupropion solute carrier family 6 member 3 Rattus norvegicus
2 Thus, bupropion acts as an antagonist at alpha3beta2* and alpha3beta4* nAChRs in rat striatum and hippocampus, respectively, across the same concentration range that inhibits DAT and NET function. Bupropion solute carrier family 6 member 3 Rattus norvegicus