Title : Mutant pso8-1 of Saccharomyces cerevisiae, sensitive to photoactivated psoralens, UV radiation, and chemical mutagens, contains a rad6 missense mutant allele.

Pub. Date : 2002 Jul

PMID : 12172962






1 Functional Relationships(s)
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1 Sequence analysis of the mutant allele showed pso8-1 to contain a novel, hitherto undescribed T-->C transition in nucleotide position 191, leading to a substitution by leucine of a highly conserved proline at position 64, Rad6-[P64L], which may have severe consequences for the tertiary structure (and hence binding to Rad18p) of the mutant protein. Leucine E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C