Title : Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning.

Pub. Date : 2002 Aug 9

PMID : 12169650






2 Functional Relationships(s)
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1 Pretreatment with N(omega)-nitro-L-arginine, a nitric oxide synthase inhibitor, or chelerythrine, a protein kinase C inhibitor (both given at doses that block late PC in this model), prevented the increase in AR protein 24 hours later, demonstrating that ischemic PC upregulates AR via nitric oxide- and protein kinase C-dependent signaling pathways. Nitroarginine aldo-keto reductase family 1 member B1 Oryctolagus cuniculus
2 Pretreatment with N(omega)-nitro-L-arginine, a nitric oxide synthase inhibitor, or chelerythrine, a protein kinase C inhibitor (both given at doses that block late PC in this model), prevented the increase in AR protein 24 hours later, demonstrating that ischemic PC upregulates AR via nitric oxide- and protein kinase C-dependent signaling pathways. Nitroarginine aldo-keto reductase family 1 member B1 Oryctolagus cuniculus