Pub. Date : 2002 Aug 15
PMID : 12167476
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In this study, curcumin was tested for its potential ability to modulate the expression and function of Pgp in the multidrug-resistant human cervical carcinoma cell line KB-V1. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) showed that treatment with 1, 5, and 10 microM curcumin for up to 72hr was able to significantly lower Pgp expression in KB-V1 cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Curcumin (1-10 microM) decreased Pgp expression in a concentration-dependent manner and was also found to have the same effect on MDR1 mRNA levels. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Curcumin (1-10 microM) decreased Pgp expression in a concentration-dependent manner and was also found to have the same effect on MDR1 mRNA levels. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The effect of curcumin on Pgp function was demonstrated by rhodamine 123 (Rh123) accumulation and efflux in Pgp-expressing KB-V1 cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | The effect of curcumin on Pgp function was demonstrated by rhodamine 123 (Rh123) accumulation and efflux in Pgp-expressing KB-V1 cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | In addition, curcumin inhibited verapamil-stimulated ATPase activity and the photoaffinity labeling of Pgp with the prazosin analog [125I]iodoarylazidoprazosin in a concentration-dependent manner, demonstrating that curcumin interacts directly with the transporter. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | In addition, curcumin inhibited verapamil-stimulated ATPase activity and the photoaffinity labeling of Pgp with the prazosin analog [125I]iodoarylazidoprazosin in a concentration-dependent manner, demonstrating that curcumin interacts directly with the transporter. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | Thus, curcumin seems to be able to modulate the in vitro expression and function of Pgp in multidrug-resistant human KB-V1 cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 11 | In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 12 | In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |