Title : N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor.

Pub. Date : 2002 Aug 15

PMID : 12166946






2 Functional Relationships(s)
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1 Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens