Title : Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain.

Pub. Date : 2002 Aug 15

PMID : 12165554






1 Functional Relationships(s)
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1 Previous analyses of gene expression in a mouse model of Huntington"s disease (R6/2) indicated that an N-terminal fragment of mutant huntingtin causes downregulation of striatal signaling genes and particularly those normally induced by cAMP and retinoic acid. Cyclic AMP huntingtin Mus musculus