Title : Novel 20-carbonate linked prodrugs of camptothecin and 9-aminocamptothecin designed for activation by tumour-associated plasmin.

Pub. Date : 2002 Sep 2

PMID : 12161136






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The tripartate prodrugs consist of a tripeptide sequence recognised by plasmin, which is linked to the 20-hydroxyl group of the camptothecins via a 1,6-elimination spacer. tripeptide K-26 plasminogen Homo sapiens