Pub. Date : 2002 Aug
PMID : 12154104
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 2 | The influence of the HMG-CoA reductase inhibitor simvastatin was assessed on the cardiovascular alterations and production of free radicals associated with chronic angiotensin II (Ang II) infusion. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 3 | The influence of the HMG-CoA reductase inhibitor simvastatin was assessed on the cardiovascular alterations and production of free radicals associated with chronic angiotensin II (Ang II) infusion. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 4 | Simvastatin (60 mg/kg per day PO) or placebo were given concomitantly for 10 days in Sprague-Dawley rats infused with Ang II (200 ng/kg per minute SC, osmotic pump). | Simvastatin | angiotensinogen | Rattus norvegicus |
| 5 | Increases in heart weight index and carotid cross-sectional area induced by Ang II were obliterated by simvastatin (3.18+/-0.09 versus 3.46+/-0.11 mg/g body wt and 0.125+/-0.010 versus 0.177+/-0.010 mm2, respectively). | Simvastatin | angiotensinogen | Rattus norvegicus |
| 6 | The Ang II-induced increases in leukocyte and aortic production of ROS as well as protein and lipid oxidation products were prevented by simvastatin. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 7 | These results indicate that simvastatin prevented the development of hypertension and cardiovascular hypertrophy together with inhibition of the induced angiotensin II production of ROS. | Simvastatin | angiotensinogen | Rattus norvegicus |