Title : Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans.

Pub. Date : 2002 Jul

PMID : 12151999






2 Functional Relationships(s)
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1 OBJECTIVE: The capacity of the non-nucleoside reverse transcriptase inhibitor efavirenz to induce either liver CYP3A4 or intestinal CYP3A4, or both, as well as intestinal P-glycoprotein, was evaluated in healthy volunteers during and after a 10-day treatment course with two different daily doses. efavirenz cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 OBJECTIVE: The capacity of the non-nucleoside reverse transcriptase inhibitor efavirenz to induce either liver CYP3A4 or intestinal CYP3A4, or both, as well as intestinal P-glycoprotein, was evaluated in healthy volunteers during and after a 10-day treatment course with two different daily doses. efavirenz cytochrome P450 family 3 subfamily A member 4 Homo sapiens